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. 2021 Aug 26;13:704583. doi: 10.3389/fnagi.2021.704583

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Copyright © 2021 Karami, Darreh-Shori, Schultzberg and Eriksdotter.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes in ChAT levels in plasma of patients in different stages of dementia. (A) The plasma ChAT activity was higher in AD compared to patients with a clinical diagnosis of MCI or SCI. (B) A similar pattern of differences was found with regard to ChAT protein levels in plasma in the three groups. (C) Plasma ChAT activity correlated with its protein concentration in all three groups. AD = Alzheimer’s disease; ChAT = choline acetyltransferase; MCI = mild cognitive impairment; SCI = subjective cognitive impairment. *p < 0.05, ***p < 0.001, ^#p < 0.07.