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. 2021 Aug 26;13:704583. doi: 10.3389/fnagi.2021.704583

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Copyright © 2021 Karami, Darreh-Shori, Schultzberg and Eriksdotter.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlations between plasma ChAT levels and global cognition and CSF tau levels. (A) Illustrates a negative significant correlation between global cognitive performance as assessed by MMSE test and the activity of ChAT in plasma. Panel (B) shows the corresponding negative significant correlation between MMSE test scores and the plasma ChAT protein. Panels (C,D) show the positive correlations between the plasma ChAT protein and the t-tau (C) and p-tau (D) levels in CSF of all subjects. The plasma ChAT activity and protein levels are given in natural logarithm (Ln). AD = Alzheimer’s disease; ChAT = choline acetyltransferase; CSF = cerebrospinal fluid; MCI = mild cognitive impairment; p-tau = phosphorylated tau181 protein; SCI = subjective cognitive impairment; t-tau = total tau protein.