Figure 4.

(a) In vivo fluorescence images of mice injected with cGAMP@dual-anti-Exos at different times. The fluorescence signal of Alexa 647 was collected under the excitation and emission wavelengths of 620 nm and 670 nm, respectively. The fluorescence signal of Alexa 488 was collected under the excitation and emission wavelengths of 460 nm and 520 nm, respectively. (b) The tumor volume changes of tumor-bearing mice after intratumor injection of different drugs. The data was recorded every two days. (c) The survival rate of different drug-treated tumor-bearing mice. (d) The body weight changes of tumor-bearing mice after intratumor injection of different drugs. (e) The photos of typical tumors dissected from mice with different treatment at day 18. (f) Bioluminescence imaging of tumor-bearing mice after intratumor injection of different drugs.