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. 2021 Aug 26;11:735940. doi: 10.3389/fonc.2021.735940

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Copyright © 2021 Johnson, Bennett, Sanidad, Hoang, Jardine, Keszenman and Wilson

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Clonogenic survival of asynchronously growing normal NFF28 primary fibroblasts pretreated for 18 h with 10 µM SAHA, 10 µM M344, and 5 µM PTACH and irradiated cesium-137 γ-rays (A), 200 MeV protons (B), 290 MeV/n C-12 ions (C), or 350 MeV/n O-16 ions (D). Data reported as mean ± SD; where error bars are not visible, they are smaller than the data point. Unlike the radioprotection observed following HDACi pretreatment in G0/G1-phase cultures irradiated with C-12 or O-16 ions, 18 h HDACi pretreatment of asynchronously growing NFF28 fibroblast cultures resulted in radiosensitization. Asterisks mark significant differences compared to DMSO controls at p-values of ≤0.05 (*) by one-way ANOVA.