Fig. 7.

Heat maps showing the mutations and their frequencies in the favipiravir‐binding site of nsp12. Mutations in the favipiravir‐binding site of SARS‐CoV‐2 nsp12 obtained from the CoV‐GLUE database are presented. The frequencies of the mutations in the reported COVID‐19 cases ranging from lower to higher numbers are shown from blue to yellow. The mutants that developed resistance towards favipiravir are marked as ‘F’ adjacent to the mutants. Out of 134 mutations obtained from the CoV‐GLUE database (in the favipiravir‐binding site of nsp12), 63 were predicted as resistant in our design computations, thus attaining ˜ 47% correlation with the sequencing data