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. 2021 Sep 1;595(18):2366–2382. doi: 10.1002/1873-3468.14182

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© 2021 Federation of European Biochemical Societies.

This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

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Fig. 8 — Intermolecular interactions between favipiravir and the RdRp complex for the top‐scoring designs. Intermolecular interactions between favipiravir and the RdRp complex for the top‐scored (A) affinity‐enhancing designs and (B) affinity‐attenuating designs. Interacting residues of corresponding nsp12 (green) and RNA bases with favipiravir (yellow) and Mg²⁺ (green sphere) coordinating the favipiravir‐RTP are shown. Hydrogen bonds are shown as black dashes. (C) 2D ligand interaction diagrams of RdRp‐favipiravir complex for the top‐scored affinity‐enhancing and (D) affinity‐attenuating design. The intermolecular interactions are labelled below.