Table 1.

Favipiravir‐interacting nsp12 residues that are designed with corresponding SNPs of the wild‐type sequence. A limited number of amino acids for each position were sampled because they are more likely to happen naturally over the evolution of the protein than others

S. No	Nsp12‐favipiravir‐interacting and designed wild‐type residues	Sampled SNPs in designs	S. No	Nsp12‐favipiravir‐interacting and designed wild‐type residues	Sampled SNPs in designs
1	His439	RNDQLPY	22	Arg624	NCQGHILKMPSTW
2	Asp452	ANEGHYV	23	Ala625	DEGPSTV
3	Tyr456	NDCHFS	24	Met626	RILKTV
4	Met542	RILKTV	25	Arg631	NCQGHILKMPSTW
5	Tyr546	NDCHFS	26	Val662	ADEGILMF
6	Ala547	DEGPSTV	27	Lys676	RNQEIMT
7	Ser549	ACLFPTWY	28	Gly679	ARDCESWV
8	Ala550	DEGPSTV	29	Thr680	ARNIKMPS
9	Lys551	RNQEIMT	30	Ser681	ACLFPTWY
10	Arg553	NCQGHILKMPSTW	31	Ala690	DEGPSTV
11	Ala554	DEGPSTV	32	Ser692	ACLFPTWY
12	Arg555	NCQGHILKMPSTW	33	Phe694	CILSYV
13	Thr556	ARNIKMPS	34	Asn695	DHIKSTY
14	Gly616	ARDCESWV	35	Ala762	DEGPSTV
15	Trp617	RCGLS	36	Val763	ADEGILMF
16	Asp618	ANEGHYV	37	Lys798	RNQEIMT
17	Tyr619	NDCHFS	38	Trp800	RCGLS
18	Pro620	ARQHLST	39	His810	RNDQLPY
19	Lys621	RNQEIMT	40	His816	RNDQLPY
20	Cys622	RGFSWY	41	Asp833	ANEGHYV
21	Asp623	ANEGHYV