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letter
. 2021 Jun 30;149(8):1619–1620. doi: 10.1002/ijc.33712

TABLE 1.

Randomized control screening trials on oral, cervix and breast cancers conducted in India

Publication 1 2 3 4 5
Location Trivandrum District, Kerala, India Dindigul District, Tamil Nadu, India Osmanabad District, Maharashtra, India Mumbai, Maharashtra, India Mumbai, Maharashtra, India
Screening test Oral visual inspection VIA screening HPV testing, Cytology and VIA screening VIA screening Clinical Breast Examination
Provider Trained Health workers Trained Nurses Trained Auxiliary nurse midwives Primary Health workers Trained female primary health workers
Sample size 191 873 80 654 131 746 151 538 151 538
Screening round 3 1 1 4 4
Surveillance Trivendrum PBCR, HBCR of RCC, source visits and household visits Dindigul district PBCR, Medical records, Source visits, House hold visits by registry staff District death‐registration offices, hospital records, annual home visits by Barshi registry staff Primarily through door to door visits and later cross checked the data with Mumbai Cancer Registry Primarily through home visits and later cross checked the data with Mumbai Cancer Registry
Outcome 34% reduction in the mortality in tobacco or alcohol users (0.66 95% CI [0.45‐0.95]) 35% Reduction in the cervical cancer mortality (0.65 95% CI [0.47‐0.89]) 53% significant reduction in rate of advanced cervical cancer (0.47 95% CI [0.32‐0.69]) and 48% reduction in associated mortality in HPV testing group (0.52 95% CI [0.33‐0.83]) 31% reduction in Mortality in the screening group (0.69 95% CI [0.54‐0.88]) Nearly 30% reduction in mortality in women ≥50 and older (0.71 95% CI [0.54‐0.94])

Abbreviations: CI, confidence interval; HBCR, Hospital Based Cancer Registry; HPV, human papillomavirus; PBCR, Population Based Cancer Registry; RCC, Regional Cancer Centre; VIA, visual inspection with acetic acid.