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. 2021 Aug 26;15:715048. doi: 10.3389/fnins.2021.715048

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Copyright © 2021 Blasi, Bolognesi, Ricci, Baglio, Zanzottera, Canevini, Walder, Cabinio, Zanette, Baglio, Clerici and Guerini.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Causal mediation analyses of SNAP-25 rs363043 on PRI and FSIQ scores of the WISC-III/IV. The Left inferoparietal and supramarginal cortex thickness as the mediators for PRI and FSIQ, respectively. The Left inferior parietal and supramarginal cortex thickness were observed to be the mediators for PRI and FSIQ, respectively. The upper part of the figure shows the association of the rs363043 polymorphism with PRI score (direct effect = 0.44; contribution of the left inferior parietal = 3.1%). The lower part of the figure shows the association of the rs363043 polymorphism with FSIQ score (direct effect = 0.56; contribution of the left Supramarginal gyrus = 3.5%).