Table 4.
Multivariate Cox regression analysis on the risk factors associated with mortality in patients with COVID‐19 from symptom onset
| Factors | Univariate analysis | Cox regression model | ||
|---|---|---|---|---|
| Hazard ratio (95% CI) | p value | Hazard ratio (95% CI) | p value | |
| Age, >65 years | 3.79 (2.32–6.20) | <.001 | 2.01 (1.03–3.92) | .04 |
| Sex | 0.53 (0.34–0.82) | .005 | ||
| Hypertension | 2.05 (1.34–3.13) | .001 | ||
| COPD | 2.95 (1.64–5.32) | <.001 | ||
| Chronic heart disease | 2.16 (1.34–3.47) | .002 | ||
| Cerebrovascular disease | 3.10 (1.72–5.59) | <.001 | ||
| Myocardial injury | 7.02 (4.45–11.08) | <.001 | 4.55 (2.49–8.31) | <.001 |
| CRP | 1.01 (1.01–1.02) | <.001 | 1.01 (1.00–1.01) | .001 |
| NT‐proBNP on admission | 1.00 (1.00–1.00) | .082 | ||
| PCT | 1.00 (1.00–1.02) | .768 | ||
| D‐dimer | 1.01 (1.00–1.01) | .003 | ||
| NCP types | <.001 | .007 | ||
| Severe‐common | 3.89 (1.95–7.76) | <.001 | 2.18 (0.92–5.15) | .075 |
| Critically severe‐common | 18.42 (9.06–37.41) | <.001 | 4.33 (1.65–11.36) | <.001 |
Note: p‐values by Cox regression analyses. PCT, CRP, and NT‐proBNP on admission, D‐dimer were performed as continuous variables. p values less than 0.05 was statistical significant (Boldface).
Abbreviations: CI, confidence interval; COPD, chronic obstructive pulmonary disease; NCP, novel coronary pneumonia; NT‐proBNP, N‐terminal pro‐B‐type natriuretic peptide; PCT, procalcitonin.