Table 3.
Common CYP Enzymes-Mediated Pharmacokinetic Drug Interactions of Acetylcholinesterase Inhibitors in Older Adults Living with Dementia
| PK Drug Interactions | CYP2D6 | CYP3A4 | Outcomes |
|---|---|---|---|
| Strong Inhibitors138,242,246–249 | Antidepressants | Antibiotics | Increased plasma concentration of donepezil and galantamine Hypercholinergic outcomes Hypersalivation, abdominal pain, diarrhea, nausea, vomiting |
| Bupropion | Erythromycin | ||
| Duloxetine | Antifungal drugs | ||
| Fluoxetine | Fluconazole | ||
| Paroxetine | Ketoconazole | ||
| Sertraline | Antiarrhythmic drugs | ||
| Antiarrhythmic drugs | Amiodarone | ||
| Amiodarone | Antipsychotics | ||
| Antipsychotics | Haloperidol | ||
| Aripiprazole | Antidepressants | ||
| Haloperidol | Sertraline |
Abbreviations: PK, pharmacokinetics; CYP, cytochrome P450; CYP2D6, cytochrome P450 2D6; CYP3A4, cytochrome P450 3A4.