In vivo peri-implant bone regeneration after 6 weeks of implantation. (A) Micro-CT scanning of the femurs containing different implants and the reconstructed 3D images. Corresponding to the bottom left colorful ruler, the cancellous bone is mainly yellow, the cortical bone is mainly blue, and the medullary cavity is black. (B–H) Quantitative analysis of BMD, Coon. D, BV/TV, BS/BV, Tb·Th and Tb. Sp (n = 6 per group). (I) Maximum interface fixation force in different groups determined by push-out testing (n = 4 per group). Statistically significant differences were indicated by *p < 0.05 and #p < 0.01 compared with the bare PEEK group.