TABLE 2.
VITT Grading Score and Relevant Clinical Parameters of included Cases with Cerebral and Central Nervous System Events within 31 days from Covid‐19 Vaccination
| Characteristics | Cerebral venous thrombosis (N = 45) | Ischemic stroke (N = 9) | Hemorrhagic stroke (N = 4) | Other (N = 4) | Total (N = 62) |
|---|---|---|---|---|---|
| Score | |||||
| 0 | 2 (4.4%) | 1 (11.1%) | 1 (25.0%) | 0 (0.0%) | 4 (6.5%) |
| 1 | 17 (37.8%) | 3 (33.3%) | 1 (25.0%) | 3 (75.0%) | 24 (38.7%) |
| 2 | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 1 (25.0%) | 1 (1.6%) |
| 2+ | 4 (8.9%) | 0 (0.0%) | 1 (25.0%) | 0 (0.0%) | 5 (8.1%) |
| 3 | 2 (4.4%) | 2 (22.2%) | 0 (0.0%) | 0 (0.0%) | 4 (6.5%) |
| 4 | 20 (44.4%) | 3 (33.3%) | 1 (25.0%) | 0 (0.0%) | 24 (38.7%) |
| PF4AK | |||||
| N‐Miss | 14 | 4 | 3 | 3 | 24 |
| Negative | 9 (29.0%) | 0 (0.0%) | 0 (0.0%) | 1 (100.0%) | 10 (26.3%) |
| Positive | 22 (71.0%) | 5 (100.0%) | 1 (100.0%) | 0 (0.0%) | 28 (73.7%) |
| VITT | |||||
| N‐Miss | 14 | 4 | 3 | 3 | 24 |
| Negative | 11 (35.5%) | 1 (20.0%) | 0 (0.0%) | 1 (100.0%) | 13 (34.2%) |
| Positive | 20 (64.5%) | 4 (80.0%) | 1 (100.0%) | 0 (0.0%) | 25 (65.8%) |
| Relative thrombocytopenia (drop >50%) | |||||
| N‐Miss | 2 | 0 | 0 | 1 | 3 |
| Negative | 41 (95.3%) | 8 (88.9%) | 3 (75.0%) | 3 (100.0%) | 55 (93.2%) |
| Positive | 2 (4.7%) | 1 (11.1%) | 1 (25.0%) | 0 (0.0%) | 4 (6.8%) |
| Thrombocytopenia (thrombocyte <150 nL) | |||||
| N‐Miss | 2 | 0 | 0 | 1 | 3 |
| No | 17 (39.5%) | 6 (66.7%) | 2 (50.0%) | 2 (66.7%) | 27 (45.8%) |
| Yes | 26 (60.5%) | 3 (33.3%) | 2 (50.0%) | 1 (33.3%) | 32 (54.2%) |
| D‐dimer ≥500 μg/L | |||||
| N‐Miss | 12 | 5 | 3 | 0 | 20 |
| No | 10 (30.3%) | 1 (25.0%) | 0 (0.0%) | 2 (50.0%) | 13 (31.0%) |
| Yes | 23 (69.7%) | 3 (75.0%) | 1 (100.0%) | 2 (50.0%) | 29 (69.0%) |
VITT = vaccine‐induced thrombocytopenic thrombosis.