Skip to main content
. 2021 Aug 26;11:679262. doi: 10.3389/fonc.2021.679262

Figure 3.

Figure 3

Identification of signatures associated with immune infiltration of BCBMs. (A) Analysis of network topology of GSE43837 dataset with different soft thresholds. The left panel shows the influence of soft threshold power (x-axis) on the scale-free fit index (y-axis). The right panel shows the influence of soft threshold power (x-axis) on mean connectivity (y-axis). (B) Dendrogram of gene clustering, the gene set was divided into 16 modules based on network topology. Different color modules contain different number of genes. (C) Heatmap shows correlations of module eigengenes with immune cell infiltration. Each cell contains the corresponding correlation and P value. (D) Venn diagram of DEGs and turquoise module eigengenes. A total of 30 overlapping genes were obtained. The full DEGs lists are provided in Supplementary Table 1. The 30 overlapping genes are provided in Supplementary Table 4. (E–G) Prognostic significances of IM-metagene in patients with breast cancer were shown based on the KM plotter database. RFS, relapse‐free survival; OS, overall survival; DMFS, distance metastasis free survival; and HR, hazard ratio. The P values were determined using a log-rank test.