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. 2021 Aug 26;11:679262. doi: 10.3389/fonc.2021.679262

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Copyright © 2021 Xiao, Zhou, Liu, Zhou, Chen, Cui and Zhao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of immune and metabolic characteristics between BCBMs and BCEMs. (A, B) ESTIMATE immune and MCP-counter analysis of BCBMs (n = 15) and BCEMs (n = 14) (GSE14017). (C, D) ESTIMATE immune and MCP-counter analysis of BCBMs (n = 7) and BCEMs (n = 29) (GSE14018). (E) Comparison of CPM for PTEN RNA expression between BCBMs (n = 15) and BCEMs (n = 14) from GSE14017, BCBRs (n = 7) and BCEMs (n = 29) from GSE14018. Significance was determined via Wilcoxon rank-sum test. (F) GSEA analysis demonstrating all KEGG metabolism significantly altered (p < 0.05, FDR < 0.25) in BCBMs versus BCEMs (GSE14017 and GSE14018). The normalized enrichment score (NES) forms the x-axis. Downregulated gene sets are shown in red. No upregulated gene sets met the criteria for statistical significance. ns, not significant; *P < 0.05, **P < 0.01, ***P < 0.001, determined by Wilcoxon rank-sum test.