Figure 7.

Schematic diagram of energy metabolism showing genes/proteins differentially regulated after dld-1 suppression in Aβ expressing worms CL4176. Green and blue boxes indicate upregulated and down regulated genes/proteins after dld-1 suppression. The suppression of dld-1 after RNAi feeding resulted in differential regulation of gene/proteins in major energy metabolic and associated pathways including glycolysis, TCA cycle, oxidative phosphorylation, amino acid metabolism, cell signaling, longevity, proteasomal and glutathione pathways.