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Regulation of gene expression by RNA modifications. (A) Chemical modification of eukaryotic mRNA. (B & C) Mechanism of m6A modification. Installation of methyl groups in m6A modification is accomplished by writers: METTL3, METTL14, WTAP, KIAA1429, METTL16 and RBM15. And the reversal of m6A methylation is mediated by erasers: FTO and ALKBH5. The altered m6A transcripts are recognized by m6A readers, and then leading to different effects on methylated mRNAs.
