Table 1.

Baseline CML patient characteristics by front-line TKI treatment.

Patient characteristics	First-line treatment				Total (N=1206)
	Imatinib (N = 608)		2GTKI (N = 598)
	N	%	N	%	N	%
Age:
median (iqr)	69	(58-77)	52	(41-63)	60	(48-71)
mean (sd)	65.7	(14.7)	51.6	(14.0)	58.6	(16.0)
18-29	16	2.6	34	5.7	50	4.1
30-39	23	3.8	94	15.7	117	9.7
40-49	51	8.4	133	22.2	184	15.3
50-59	81	13.3	148	24.7	229	19.0
60-69	139	22.9	129	21.6	268	22.2
70-79	192	31.6	52	8.7	244	20.2
+80	106	17.4	8	1.3	114	9.5
Sex:
Male	383	63.0	344	57.5	727	60.3
Female	225	37.0	254	42.5	479	39.7
Period of diagnosis:
2013-2015	113	18.6	172	28.8	285	23.6
2016-2017	257	42.3	261	43.6	518	43.0
2018-2020	238	39.1	165	27.6	403	33.4
Comorbidity:
Cardiovascular disease	238	39.1	90	15.1	328	27.2
Pulmonary disease	110	18.1	33	5.5	143	11.9
Metabolic disease	75	12.3	29	4.8	104	8.6
Other neoplasm	61	10.0	31	5.2	92	7.6
Charlson index score:
2	359	59.0	489	81.8	848	70.3
3	104	17.1	48	8.0	152	12.6
4	80	13.2	26	4.3	106	8.8
5	46	7.6	19	3.2	65	5.4
not available	19	3.1	16	2.7	35	2.9
CML Phase:
chronic	590	97.0	574	96.0	1164	96.5
blastic	3	0.5	2	0.3	5	0.4
accelerated	7	1.2	12	2.0	19	1.6
not available	8	1.3	10	1.7	18	1.5
ELTS score:
Low	305	51.3	390	66.9	695	59.0
Intermediate	211	35.5	128	22.0	339	28.8
High	79	13.3	65	11.1	144	12.2
not available	13	2.1	15	2.5	28	2.3
Sokal score:
Low	164	27.7	261	44.8	425	36.1
Intermediate	340	57.3	201	34.5	541	46.0
High	89	15.0	121	20.8	210	17.9
not available	15	2.5	15	2.5	30	2.5