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. 2021 Aug 26;11:727605. doi: 10.3389/fonc.2021.727605

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Copyright © 2021 Yang, Sun, Liu, Liu, Zhang, Zhou, Qiu and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ERN, LP-ERN and Tf-LP-ERN suppressed the tumor growth and showed biological safety in SMMC-7721-xenotransplanted BALB/c mice. The tumor volume comparison in (A) SMMC-7721-xenotransplanted BALB/c mice, and (B) their collected tumors (n = 6). Tf-LP, ERN, LP-ERN and Tf-LP-ERN showed no significant effects (C) on the body weight and (D) histopathologic changes including liver, spleen and kidney in SMMC-7721-xenotransplanted mice (magnification: 200, scale bar: 50 μm).