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. 2021 Aug 26;11:727605. doi: 10.3389/fonc.2021.727605

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Copyright © 2021 Yang, Sun, Liu, Liu, Zhang, Zhou, Qiu and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of ERN, LP-ERN and Tf-LP-ERN on inflammatory factor in serum of SMMC-7721-tumor-bearing mice. (A) ERN, LP-ERN and Tf-LP-ERN significantly reduced the levels of IL-10, CCL11, and enhanced the level of TNF-α (n = 6). (B) In spleens of SMMC-7721-xenografted mice, ERN, LP-ERN and Tf-LP-ERN increased the expression levels of Nrf2 and its downstream proteins HO-1, SOD-1, SOD-2, while reduced the expression levels of P-IKKα+β, and P-NF-κB, among which, Tf-LP-ERN showed the best efficacy. Quantification data were normalized by GAPDH or the corresponding total proteins and were reported as the folds of those from the corresponding CTRL mice (n = 3). The data were analyzed using a one-way analysis of variance and expressed as means ± S.D. (n = 3). *P < 0.05 and **P < 0.01 vs. control cells.