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. 2021 Aug 26;11:740083. doi: 10.3389/fonc.2021.740083

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Copyright © 2021 Kolijn, Muggen, Ljungström, Agathangelidis, Wolvers-Tettero, Beverloo, Pál, Hengeveld, Darzentas, Hendriks, Dongen, Rosenquist and Langerak

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Family trees and BcR IG characteristics of familial CLL cases. (A) Family 1 consists of two brothers and two sisters who carry mutated IGHV genes. (B) Family 2 consists of two brothers who both carry unmutated IGHV genes. (C) Family 3 consists of two brothers and two sisters. In all four siblings, the CLL clone utilizes the IGLV3-21*04 gene with the characteristic R110 mutation and the K16 and YDSD motifs. Additionally, siblings 3B and 3C express similar IGHV genes, i.e. IGHV3-21 and IGHV3-48, and belong to stereotyped subsets #2 and #169, respectively.