Figure 2.

Somatic mutations and germline variants detected by whole genome sequencing of the CLL families. In this figure, both germline variants (A) and somatic genetic alterations (B) detected in the CLL families are shown. The genes highlighted in bold text are genes, which have previously been identified as CLL driver genes. Genes that are not in bold text were identified during KEGG pathway analysis. Only mutations/variants with likely functional consequences related to CLL development are shown; mutations/variants that were previously reported to be benign or evaluated as benign by variant effect predictors were not shown.