Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Aug 26;9:680600. doi: 10.3389/fcell.2021.680600

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Xie, Cai, Tang, Jiang, Zhou, Yang, Liu, Wang, Zhao, Zhao and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Flubendazole inhibited the STAT3 signaling pathway. (A) Expression levels of p-STAT3, STAT3, VEGF, and MCL-1 based on western blotting assays. (B) Flubendazole (2 μM) inhibited P-STAT3 in a time-dependent manner. (C) Expression of p-STAT3 and STAT3 detected by western blotting in H460 cells transfected using si-NC or si-STAT3 (si398, si978, and si1070) for 48 h. (D) Inhibitory effects of flubendazole on the proliferation of H460 cells after transfection with si-NC or si-STAT3 (si398). GAPDH as a loading control. Outcomes are representative of three independent experiments (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001).