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. 2021 Aug 26;9:680600. doi: 10.3389/fcell.2021.680600

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Copyright © 2021 Xie, Cai, Tang, Jiang, Zhou, Yang, Liu, Wang, Zhao, Zhao and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Flubendazole inhibited nuclear translocation of STAT3. (A) Expression of STAT3 in the cytosol and in the nucleus confirmed by western blotting assays. (B) Representative confocal microscopic images indicating the localization of p-STAT3 (green) and DAPI in PC-9 cells. (C) The expression levels of STAT3 in nuclear and cytosolic fractions were determined by using the western blot analysis. Images shown are representative of three separate experiments (*P < 0.05, **P < 0.01, ***P < 0.001).