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. 2021 Aug 26;9:666422. doi: 10.3389/fcell.2021.666422

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Copyright © 2021 Xie, Yao, Hu, Cai, Zhao, Yuan, Wu and Tang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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High-mobility group A1 (HMGA1) deficiency reduced cardiac fibroblast proliferation and activation in vitro. (A) The protein level of HMGA1 in fibroblasts transfected with HMGA1 siRNA (n = 6). (B–D) CFs were transfected with HMGA1 siRNA and stimulated with TGFβ1 for 24 h. (B) Cell proliferation detected by CCK8 assay (n = 6). (C) Immunofluorescence staining of PCNA (n = 5). (D) Immunofluorescence staining of α-SMA (n = 5). (E) Transcription levels of collagen I, collagen III, and CTGF (n = 6). *p < 0.05.