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. 2021 Aug 26;9:666422. doi: 10.3389/fcell.2021.666422

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Copyright © 2021 Xie, Yao, Hu, Cai, Zhao, Yuan, Wu and Tang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FOXO1 inhibition attenuated HMGA1-induced cardiac dysfunction. (A) The protein level of FOXO1 in mouse hearts 3 weeks after AAV9-shFOXO1 injection (n = 6). (B) PSR staining image and quantitative result of left ventricular collagen volume in mouse hearts 28 days after Ang II infusion (n = 5). (C) Transcription levels of collagen I, collagen III, and TGFβ1 (n = 6). (D) Protein levels of collagen III and α-SMA in heart tissue (n = 6). (E) Echocardiographic results in each group (n = 10). *p < 0.05.