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. 2021 Aug 26;8:707295. doi: 10.3389/fmolb.2021.707295

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Copyright © 2021 Wu, Wang, Li, Wang, Jia, Feng, Huo, Yang, Jin, Sa, Gao and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HMGA2 was knocked out in a biallelic manner and overexpressed successfully in two human gastric cancer cell lines. Sanger sequencing results of HMGA2 in HMGA2-P MKN-45 (A), HMGA2-KO MKN-45 (B), HMGA2-P MGC-803 (F), and HMGA2-KO MGC-803 (G). Red lines in (A) and (F) indicate the deleted bases of HMGA2 in HMGA2-KO MKN-45/MGC-803, respectively. The expressions of HMGA2 in the mRNA level in HMGA2-edited MKN-45 cells (C) and MGC-803 cells (H) were detected. The expressions of HMGA2 in the protein level in HMGA2-edited MKN-45 cells (D,E) and MGC-803 cells (I,J) are shown. ***p < 0.001, Student’s t-test. The error bars represent SD.