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. 2021 Aug 26;15:699736. doi: 10.3389/fncel.2021.699736

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Copyright © 2021 Jia, He, Li, Wang, Jia, Hao, Lai, Zang, Chen and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The comparison of BBB breakdown between the c-ICH and the b-ICH groups. (A) The Evans blue staining showed that BBB leakage was present from 6 h to day 5 after ICH in two groups. (B) Quantitative analysis showed that the Evans blue (EB) concentration peaked at day 3 in the c-ICH group but on day 5 in the b-ICH group (n = 6 mice/group for each time point; *P < 0.05 vs. sham group, ^#P < 0.05 vs. the c-ICH group; repeated measures ANOVA followed by Bonferroni post-hoc test). (C) The IgG-positive area was determined by immunohistochemical staining on days 3 and 5, respectively (scale bar = 1 mm). (D,E) Quantification of endogenous IgG-positive area and gray values of IgG immunostaining; n = 3 mice/group; ^#P < 0.05 vs. c-ICH group (t-test). Values are Mean ± SD.