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Angiogenesis-related gene and protein expression in DPSCs. (A) VEGF gene expression was increased by 50 ng/mL Nell-1 treatment in days 3, 7, and 14. (B) Flk-1 gene expression was increased by 50 ng/mL Nell-1 treatment in days 3 and 7. (C,D) Flk-1 protein expression was increased by 50 and 100 ng/mL Nell-1 treatment in days 3 and 7. Data are shown as the mean ± SD. (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001).
