FIGURE 1.

Functions of long non-coding RNAs. Long non-coding RNAs (lncRNAs) are a diverse class of molecules that are distributed throughout the cell. The function of lncRNAs are dependent, in part, on their subcellular localization. Here, we illustrate known lncRNA functions in the nucleus and the cytoplasm. Our review focuses on the nuclear function of lncRNAs. This figure was adapted; it was originally published in Current Opinion in Pharmacology, Volume 45, Hon-Sum Jeffrey Man and Philip A Marsden, LncRNAs and epigenetic regulation of vascular endothelium: genome positioning system and regulators of chromatin modifiers, pp. 72–80, Copyright Elsevier, 2019.