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. 2021 Aug 26;15:652817. doi: 10.3389/fnins.2021.652817

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Copyright © 2021 Liu, Cheng, Chen, Lv, Zheng, Huang, Xia and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inflammatory cytokines are upregulated in POFS rats and relived by GRb1 in serum and hippocampus. (A–C) ELISA detects the Level of IL-1β, IL-6, and TNF-α (pg/ml) in rats’ serum (n = 8, each group), respectively. (D–F) RT-PCR detects the mRNA expression fold change of IL-1β, IL-6, and TNF-α in rats’ hippocampus (n = 8, each group), respectively. PG, POFS model group; CG, Control group; GG, Ginsenoside Rb1-treated POFS model group; ***p < 0.001, **p < 0.01 vs. the control group and ^###p < 0.001, ^##p < 0.01, ^#p < 0.05 vs. the PG at the same time point, respectively (two-way ANOVA with LSD test). Each bar represents mean ± SD.