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. 2021 Aug 26;15:652817. doi: 10.3389/fnins.2021.652817

FIGURE 4.

FIGURE 4

Indoleamine 2,3-dioxygenase (IDO) mediated Tryptophan degrading pathway activated in POFS rats’ hippocampus and be reversed by GRb1. (A) Representative bands of western blot of IDO and β-actin in different groups. (B) Levels of the relative expression of IDO/β-actin in hippocampus (n = 8, each group). (C) HPLC detects the concentration of tryptophan in hippocampus (nmol/g tissue) (n = 8, each group). (D) HPLC detects the concentration of kynuramine in hippocampus (nmol/g tissue) (n = 8, each group). (E) HPLC detects the concentration of serotonin (5-HT) in hippocampus (nmol/g tissue) (n = 8, each group). (F) The ratio of kynuramine/tryptophan (%) in hippocampus (n = 8, each group). PG, POFS model group; CG, Control group; GG, Ginsenoside Rb1-treated POFS model group; ***p < 0.001, **p < 0.01, *p < 0.05 vs. the control group and ##p < 0.01, #p < 0.05 vs. the PG at the same time point, respectively (two-way ANOVA with LSD test). Each bar represents mean ± SD.