Skip to main content
. 2021 Aug 26;12:718621. doi: 10.3389/fimmu.2021.718621

Figure 1.

Figure 1

Blocking TCR/CAR Mediated Activation of PI3K Signaling in T cells. TCR/CAR binding by antigen results in downstream signaling through PI3K δ/γ, AKT, and mTORC1. This signal cascade promotes AKT mediated proliferation, aerobic glycolysis, and FOXO1 inhibition, and loss of TCF1/7 and the stem-cell like epigenetic markers phosphorylated EZH2 and H3K27me3, leading effector T-cell generation. PI3K δ/γ reverse these effects and in turn increasing proliferative signaling through MEK and ERK, increase mitochondrial fusion, and promote epigenetic changes associated with T cell stemness.