Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Antigen stimulation induces T-cell differentiation and associated changes in T-cell metabolism and size. Naïve, stem cell, and central memory phenotype T cells are smaller and associated with catabolic metabolism. Antigen stimulation of the TCR signals through PI3K and mTORC1 to induce metabolic reprogramming, increase in T cell size, and eventual senescence.
