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PI3K-δ and -γ in the Tumor Microenvironement. PI3K-δ and -γ signaling Tregs, TAMs, and MDSCs regulates suppression and trafficking of CD8+ tumor infiltrating lymphocytes in the TME. PI3K-δ signaling drives Treg suppression of CD8+ tumor-infiltrating T-cells while TAMs and MDSCs rely on PI3K-γ for their immunosuppressive function.
