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. 2021 Aug 26;12:728082. doi: 10.3389/fimmu.2021.728082

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Copyright © 2021 Peng, Zhang, Ma, Zhou, Wu, Song, Yuan, Chen, Li, Wang, Huang, Qiao, Xia, Liu, Liu, Zhang, He, Pan, Xu and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Targeting Brd4 with inhibitors dampens effector CD8⁺ T cells-mediated antiviral immunity. (A) Experiment design. (B) Flow cytometry showing the expression of CD8 (left), the quantification of total CD8⁺ T cells (middle) and the quantification of LCMVgp33 epitope-specific CD8⁺ T cell numbers (right). (C) Flow cytometry showing the expression of KLRG1 and CD127 in LCMVgp33 epitope-specific CD8⁺ T cells from mice treated with JQ1 or DMSO at day 8 post-infection (left) and the frequency and number of each subset (right). (D, E) Flow cytometry analysis of indicated cytokines production after peptide stimulation in CD8⁺ T cells from mice treated with JQ1 or DMSO (left) and the number and frequency (right) of cytokine-producing CD8⁺ T cells. The data were analyzed by two-tailed unpaired t-test between two independent groups. Results were indicated as mean ± sem (error bars). *p < 0.05; **p < 0.01; ***p < 0.001. Each group includes at least 4 mice and each experiment repeats more than 2 times.