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. 2021 Aug 26;12:728082. doi: 10.3389/fimmu.2021.728082

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Copyright © 2021 Peng, Zhang, Ma, Zhou, Wu, Song, Yuan, Chen, Li, Wang, Huang, Qiao, Xia, Liu, Liu, Zhang, He, Pan, Xu and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematics showing that Brd4 regulates CD8⁺ T cell homeostasis and proliferation through controlling glucose metabolism. Brd4 maintains naïve CD8⁺ T cells homeostasis by regulating the survival and trafficking of naïve CD8⁺ T cells in steady-state. Brd4 promotes efficient glucose uptake by upregulating GLUT1 (glucose transporter 1) and Myc expression, which glucose oxidation in mitochondria fuels naïve CD8⁺ T cells survival and trafficking. Upon activation, activated CD8⁺ T cells increase glucose uptake to meet the bioenergetic and biosynthetic demands, which includes quick proliferation, survival and effector differentiation.