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BBimfl/fl mice exhibit hypergammaglobulinemia and increased ASCs. Quantification of serum immunoglobulins and ASCs in WT and BBimfl/flmice. (A) IgM and IgG2a/c levels in serum from mice ≤ 12 weeks old (B) IgM and IgG2a/c levels in mice ≥ 12 weeks old mice. Numbers of (C) IgM and IgG2a/c ASCs in splenocytes in mice ≥ 12 weeks old. Data is representative of >3 independent experiments. Not significant (N.S) P > 0.05, *P ≤ 0.05, **P ≤ 0.01, calculated by Students T-test.
