Table 2.
Risk of LT Recipients of No or Only a Low Humoral Immune Response After Second SARS-CoV-2 Vaccination Based on the Trimer Immunoassay
| Univariate OR (95% CI) | P | Multivariate OR (95% CI) | P | |
|---|---|---|---|---|
| Age >65 y | 6.21 (2.18–17.69) | .001 | 4.57 (1.48–14.05) | .008 |
| Sex (male) | 2.10 (1.04–4.22) | .038 | ||
| Vaccination regimen | 1.47 (0.71–3.04) | .300 | ||
| LT <1 y before vaccination | 2.94 (0.98–8.88) | .055 | ||
| Obesity (BMI ≥30 kg/m2) | 0.74 (0.28–2.01) | .557 | ||
| eGFR <45 mL/min | 11.10 (3.07–40.15) | < .001 | N/A | |
| Arterial hypertension | 2.82 (1.37–5.83) | .005 | 2.50 (1.10–5.68) | .028 |
| Diabetes | 2.48 (1.05–5.84) | .038 | 1.78 (0.67–4.77) | .251 |
| CNI monotherapy | 0.26 (0.11–0.63) | .003 | 0.36 (0.13–0.99) | .049 |
| CNI + MMF | 3.08 (1.47–6.45) | .003 | 1.78 (0.74–4.30) | .198 |
| CNI + mTORi | 1.94 (0.66–5.68) | .227 | ||
| CNI + azathioprine | 0.29 (0.06–1.43) | .127 | ||
| CNI + prednisone | 0.49 (0.17–1.40) | .183 | ||
| No CNI | 4.77 (0.97–23.38) | .054 | ||
| Prednisone >5 mg | 1.32 (0.38–4.56) | .659 | ||
| Triple immunosuppression | 2.42 (0.85–6.87) | .098 | ||
| Biological | 3.46 (0.67–17.79) | .138 | ||
| Re-cirrhosis | 0.38 (0.10–1.48) | .161 | ||
| IgG <13.8 g/L | N/A | |||
| IgA <3.9 g/L | N/A | |||
| IgM <1.8 g/L | 3.71 (0.35–38.93) | .275 | ||
| Lymphocytes <1000/μl | 1.36 (0.46–4.07) | .578 | ||
| B-lymphocytes <80/μl | 3.33 (1.01–10.99) | .048 | N/A | |
| T-lymphocytes <900/μl | 1.07 (0.35–3.28) | .910 | ||
| NK-cells <35/μl | 0.46 (0.04–5.42) | .537 | ||
| CD4+ cells <400/μl | 0.80 (0.27–2.42) | .695 | ||
| CD8+ cells <290/μl | 1.09 (0.37–3.24) | .875 | ||
| CD4/CD8 ratio <0.6 | N/A |
Note: For laboratory values, the lower levels of normal were set as thresholds.
Note: Bold values indicate statistical significance.
BMI, Body mass index; CI, confidence interval; CNI, calcineurin inhibitor; eGFR, estimated glomular filtration rate; LT, liver transplantation; MMF, mycophenolate mofetil; mTORi, mTOR inhibitor; N/A, not applicable: laboratory values that were not considered for univariate or multivariate analysis because of insufficient baseline values; OR, odds ratio; SARS-CoV-2, severe acute respiratory syndrome coronavirus type 2.