Supplementary Table 4.

Risk of Vaccination Failure in LT Recipients With More Than One Negative Prognostic Predictor

			Proportion of patientswith anti-S trimer <100 BAU/mL, % (n/N)	Ratio of relative risk
CNI and other	Age >65 y	eGFR <45 mL/min	100 (7/7)	6.25
		eGFR ≥45 mL/min	100 (6/6)	6.25
	Age ≤65 y	eGFR <45 mL/min	87 (13/15)	5.44
		eGFR ≥45 mL/min	45 (22/49)	2.81
CNI mono	Age ≤65 y	eGFR ≥45 mL/min	16 (3/19)	1
		eGFR <45 mL/min	75 (3/4)	4.69
	Age >65 y	eGFR ≥45 mL/min	1/1
		eGFR <45 mL/min	0

Anti-S trimer, Anti-SARS-CoV-2 antibodies in DiaSorin LIAISON immunoassay; BAU, binding antibody units; CNI, calcineurin inhibitor; eGFR, estimated glomerular filtration rate; LT, liver transplant.

The table illustrates the risk of vaccination failure, defined by anti-S trimer <100 BAU/mL, in LT recipients with a combination of several risk factors. The percentage of patients with vaccination failure in the respective patient group is indicated. Also, the relative risk compared with LT patients with optimal prognostic parameters (ie, CNI monotherapy plus ≤65 years plus eGFR ≥45 mL/min) is given.

Colors visualize the relative risk: green 1.0, yellow >1 and ≤4, orange >4 and ≤6, red >6, grey: not available due to low number of subjects)