Fig. 4.

αSyn PFF-Injection Spurs Aβ Plaque Deposition in L85 but Not dTg Mice. A-C Representative images showing IHC using antibodies specific for Aβ (AB5), on sections from 10-month-old (4 m.p.i.) L85 and dTg mice injected with PBS (A), αSyn PFFs (B), and 8-month-old (2 m.p.i.) L85 and dTg mice injected with αSyn PFFs (C). D Grouped scatter plots depicting semi-quantitative analysis of AB5-positive plaques comparing L85 and dTg mice from 8-month and 10-month aged cohorts. Two-Way ANOVA followed by Holm-Sidak’s multiple comparisons (n = 8,8,10; 6,8,11). Data are presented as mean +/− SEM. Scale bars: high magnification = 200 μm; low magnification = 25 μm