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. 2021 Sep 4;15:3735–3747. doi: 10.2147/DDDT.S314767

Figure 1.

Figure 1

BM prevented TBHP-induced oxidative stress in rat chondrocytes. (A) Effects of different concentrations (0, 0.025, 0.05, 0.075, 0.1, and 0.2 µM) of BM on rat chondrocyte viability. (B) 0.01, 0.025, 0.05, and 0.075 µM BM increased viability of rat chondrocytes treated with 25 mM THBP. (C and D) 0.025 and 0.05 µM effectively reduced MDA level and increased SOD level in rat chondrocytes treated with 25 mM THBP. (E and F) Chondrocytes were stained with DCFH-DA and measured by flow cytometry to determine the ROS level. The results showed that 0.025 and 0.05 µM BM effectively decreased ROS level in rat chondrocytes treated with 25 mM THBP. (G) Represent images of chondrocytes stained with DCFH-DA under confocal microscopy. Scale bar, 100 µm. (H) The structural formula of BM. *P < 0.05 and **P < 0.01.