Fig. 6.

Loss of STAT3 attenuates myocardial injury in mice with sepsis and reverses the effect of miR-193-3p inhibition on septic mice. A Western blot detected STAT3 protein expression. B–G Echocardiographic parameters and hemodynamic indexes of mice; H–J ELISA detected cTnI, BNP and HMGB1 in the serum; K–M ELISA detected LDH, CK and CK-MB expression levels; N–P ELISA detected TNF-α, IL-6 and IL-1β levels; n = 15; *P < 0.05 vs. the CLP + siRNA-NC group; ^#P < 0.05 vs. the CLP + miR-193-3p antagomir + siRNA-NC group