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. 2021 Aug 24;12:717544. doi: 10.3389/fendo.2021.717544

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Copyright © 2021 Lu, Huang, Huang, Feng, Clark and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Biological maturation of LEAP-2. PreproLEAP2 is processed into proLEAP2 and then the 40-residue mature LEAP-2 by signal peptidase and furin-like endoprotease. Mature LEAP-2 subsequently degrades into small metabolites through proteolytic processing. The LEAP-2 sequences of human and mouse are labelled in black and orange, respectively.