Table 4.
Changes in circulating and expression levels of LEAP-2 and ghrelin post bariatric surgeries.
| Short-term post-surgery | Long-term post-surgery | Ref. | ||
|---|---|---|---|---|
| RYGB | ||||
| LEAP-2 | Plasma level | ↔ | ↓ | (14) |
| Expression | ↑ small intestine | NA | (14) | |
| Ghrelin | Plasma level | ↓ | ↑ | (58) |
| LEAP-2/Ghrelin ratio | ↑ | ↓ | ||
| VSG | ||||
| LEAP-2 | Plasma level | NA | ↓ | (10) |
| Expression | ↑ in stomach ↓ in duodenum |
NA | (5) | |
| Ghrelin | Plasma level | NA | ↓ | (10) |
| Expression | ↓ in stomach | NA | (5) | |
| LEAP-2/Ghrelin ratio | NA | ↔ | (10) | |
RYGB, Roux-en-Y gastric bypass; VSG, vertical sleeve gastrectomy; ↑, increase; ↓, decrease; ↔, no change; NA, Not applicable.