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. 2021 Aug 26;12:687487. doi: 10.3389/fpsyt.2021.687487

Figure 5.

Figure 5

Linear regression indicated a significant interaction between top SNP rs711533 of a clump containing 9 SNPs in the CLOCK gene and exposure to childhood adversity (CHA) on current depression symptoms (BSI-Dep) in the dominant (A) and additive (B) models, with the minor C allele being a risk allele. Linear regression indicated a significant interaction between CLOCK rs711533 genotype and childhood adverse life events (CHA) on current depression scores according to the dominant and additive models as top SNP (p = 0.0006, FDR Q = 0.0118). Presence of the minor C allele was associated with higher depression scores in subjects exposed to more severe childhood adverse events conveying a risk effect. On the vertical axis weighted depression (BSI-Dep) scores are shown. The horizontal axis shows childhood adverse life events (CHA) as measured by an instrument derived from the CTQ (30). BSI-Brief symptom inventory. Gray shading denotes 95%CI.