Table 1.
Variants of concern according to the Centers for Disease Control and Prevention, on December 8, 2021
| Nextstrain Clade(b) | WHO Classification | Pango Lineage(a) | Sequence change | Spike Protein Substitutions | First Identified |
|---|---|---|---|---|---|
| 20I/501Y.V1 | Alpha | B.1.1.7 |
Δ(21,767 ~ 21,773) Δ(21,991 ~ 21,993) |
69 ~ 70 del 144del | United Kingdom |
| G23012A | (E484K*) | ||||
| T23042C | (S494P*) | ||||
| A23063T | N501Y | ||||
| C23271A | A570D | ||||
| A23403G | D614G | ||||
| C23604A | P681H | ||||
| C23709T | T716I | ||||
| T24506G | S982A | ||||
| G24914C | D1118H | ||||
| G25135C | (K1191N*) | ||||
| 20H/501.V2 | Beta |
B.1.351 B.1.351.2 B.1.351.3 |
A21801C | D80A | South Africa |
| A22206G | D215G | ||||
| Δ(22,283 ~ 22,291) | 241 ~ 3 del | ||||
| G22813C | K417N | ||||
| G23012A | E484K | ||||
| A23063T | N501Y | ||||
| A23403G | D614G | ||||
| C23664T | A701V | ||||
| 20 J/501Y.V3 | Gamma |
P.1 P.1.1 P.1.2 |
C21614T | L18F |
Japan Brazil |
| C21621A | T20N | ||||
| C21638T | P26S | ||||
| G21974T | D138Y | ||||
| G22132C | R190S | ||||
| A22812C | K417T | ||||
| G23012A | E484K | ||||
| A23063T | N501Y | ||||
| A23403G | D614G | ||||
| C23525T | H655Y | ||||
| C24642T | T1027I | ||||
| 21A/S:478 K | Delta |
B.1.617.2 AY.1 AY.2 AY.3 |
C21618G |
T19R (V70F*) T95I |
India |
| G21770T | |||||
| C21846T | |||||
| G21987A | |||||
| Δ(22,028 ~ 22,033) | G142D | ||||
| A22034G | E156- F157- | ||||
| C22227T | R158G | ||||
| G22335T | (A222V*) | ||||
| G22813C | (W258L*) | ||||
| T22917G | (K417N*) | ||||
| C22995A | L452R | ||||
| A23403G | T478K | ||||
| C23604G | D614G | ||||
| G24410A | P681R | ||||
| D950N |
(*) = detected in some sequences but not all
aPhylogenetic Assignment of Named Global Outbreak (PANGO) Lineages is a software tool developed by members of the Rambaut Lab. The associated web application was developed by the Centre for Genomic Pathogen Surveillance in South Cambridgeshire and is intended to implement the dynamic nomenclature of SARS-CoV-2 lineages, known as the PANGO nomenclature
bNextstrain, a collaboration between researchers in Seattle, USA and Basel, Switzerland, provides an open-source tool for visualizing the genetics of outbreaks. The goal is to support public health surveillance by facilitating understanding of the spread and evolution of pathogens