Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Potency of SHR2554 against wild-type and mutant EZH2.
| Genes | IC50 (nM) | |
|---|---|---|
| SHR2554 | EPZ6438 | |
| EZH2 | 0.87 ± 0.02 | 0.96 ± 0.24 |
| EZH2(Y641C) | 16.80 ± 1.46 | 11.05 ± 1.43 |
| EZH2(Y641F) | 2.68 ± 0.41 | 2.44 ± 0.03 |
| EZH2(Y641N) | 1.79 ± 0.55 | 1.93 ± 0.23 |
| EZH2(Y641S) | 5.07 ± 0.24 | 4.45 ± 0.59 |
| EZH2(Y641G) | 1.13 ± 0.04 | 0.69 ± 0.18 |
