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. 2021 Aug 24;13(17):4265. doi: 10.3390/cancers13174265

Figure 4.

Figure 4

Ad5/MUC16-1040/TK-EGFP replicates in primary ovarian cancer cells. (A). Case 1 from malignant pleural effusion. Upper panel: Confirmation of high-grade serous ovarian cancer with expression of CA-125, PAX8, WT-1, and p53 (mutated pattern with abnormal strong diffuse expression), negative for calretinin; lower panel: Ad5/MUC16-1040/TK-EGFP replicates in primary ovarian cancer cells indicated by expression of EGFP signal, scale bar: 20 μm, magnification: 400×. (B). Case 2 from ascites. Upper panel: Confirmation of high-grade serous ovarian cancer with expression of CA-125 and PAX8, negative for p53 (null pattern); lower panel: predominant cancer cells with EGFP expression, indicating virus replication, scale bar: 100 μm, magnification: 100×.

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