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. 2021 Aug 24;13(17):4266. doi: 10.3390/cancers13174266

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Suppression of tumor growth and colony formation by piperlongumine (PL) in vitro in human thyroid cancer cells. Three types of human thyroid cancer cells, namely, papillary thyroid cancer (PTC) (IHH-4), follicular thyroid cancer (FTC) (WRO), and anaplastic thyroid cancer (ATC) (8505c and KMH-2), were incubated with PL, and the (A) cellular viability and (B) colony formation were examined. Dimethyl sulfoxide (DMSO) was used as a negative control. Three independent experiments of cellular viability were conducted. Compared with the control group, * indicates p < 0.05, ** indicates p < 0.01, *** indicates p < 0.001.